Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation
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چکیده
Results: TT treatment of diabetic rats reduced pain score only in chronic phase of the formalin test (p<0.05). Meanwhile, SS administration significantly reduced pain score only at chronic phase of the test (p<0.05). Regarding hot tail immersion test, diabetic rats showed a significant reduction in tail flick latency as compared to control ones (p<0.05). Although TT treatment of diabetic rats increased this latency relative to untreated diabetics but the existing difference was not statistically significant. TT treatment of diabetic rats also significantly reduced MDA level versus untreated diabetics (p<0.01).
منابع مشابه
Antinociceptive activity of Tribulus terrestris oral feeding in diabetic rats: Involvement of lipid peroxidation
Background and Objective: Due to the presence of some evidence for anti-diabetic and antioxidant activity of Tribulus terrestris (TT), this study was designed to investigate the anti-nociceptive effect of TT in streptozotocin-diabetic rats using formalin test and hot tail immersion tests. Materials and Methods: Rats were divided into control, TT-treated control, diabetic, sodium salicylate (SS)...
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Introduction: Chronic diabetes mellitus in the long run accompanies enhanced oxidative stress burden and decreases activity of antioxidant defense system. Due to significant role of these factors in development of some neurological disorders and with regard to antidiabetic and antioxidant effect of Tribulus terrestris (TT), this study was conducted to evaluate the effect of its oral administrat...
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